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KMID : 0355620160420060358
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Journal of Korean Association of Oral and Maxillofacial Surgeons
2016 Volume.42 No. 6 p.358 ~ p.364
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Elective neck dissection versus observation in early stage oral squamous cell carcinoma: recurrence and survival
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Kim Dong-Wook
Lee Ba-Da
Lim Jung-Hwan
Park Jung-Hyun
Nam Woong
Kim Hyung-Jun
Cha In-Ho
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Abstract
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Objectives: To evaluate the results of elective neck dissection versus those of observation in the treatment of early stage oral squamous cell carcinoma and to identify factors related to recurrence and survival.
Materials and Methods: This was a retrospective study of 52 patients who underwent elective neck dissection and 27 who did not receive neck dissection.
Results: In survival analyses, elective neck dissection showed a benefit in overall recurrence (P=0.027), especially in stage I patients (P=0.024). With regard to survival, the benefit was statistically insignificant (P=0.990). In multivariable analysis, overall recurrence was independently related to poor histologic grade (odds ratio [OR]=9.65, P=0.006), and cancer-specific death was independently related to advanced age (OR=6.3, P=0.022), higher clinical T stage (OR=15.2, P=0.01), and poorly differentiated histologic grade (OR=6.6, P=0.025).
Conclusion: Though there was lower recurrence in the elective neck dissection group, there were no statistically significant results on survival. The characteristics of the tumor itself, such as clinical T stage and poor histologic grade, may be more important in cancer-specific survival.
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KEYWORD
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Oral cancer, Squamous cell carcinoma, Neck dissection, Survival analysis, Survival rate
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